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Synthesis, docking and evaluation of novel fused pyrimidine compounds as possible lead compounds with antibacterial and antitumor activities.

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Israa University
Morjan R.Y.; El-Hallaq A.F.; Azarah J.N.; Almasri I.M.; Alzaharna M.M.; Al-Reefi M.R.; Beadham I.; Abu-Teim O.S.; Elmanama A.A.; Awadallah A.M.; Raftery J.; Gardiner J.M.
Morjan, Rami Y. (55547465500); El-Hallaq, Amany F. (58154462000); Azarah, Jannat N. (57203817947); Almasri, Ihab M. (36573119700); Alzaharna, Mazen M. (55596003100); Al-Reefi, Mariam R. (58154617000); Beadham, Ian (6507809890); Abu-Teim, Omar S. (15844819400); Elmanama, Abdelraouf A. (8717617200); Awadallah, Adel M. (6701728900); Raftery, James (7004558116); Gardiner, John M. (35310215400)
55547465500; 58154462000; 57203817947; 36573119700; 55596003100; 58154617000; 6507809890; 15844819400; 8717617200; 6701728900; 7004558116; 35310215400
2023
Journal of Molecular Structure
Synthesis, docking and evaluation of novel fused pyrimidine compounds as possible lead compounds with antibacterial and antitumor activities.
1288
Elsevier B.V.
135754
Department of Chemistry, Islamic University of Gaza, P.O. Box108, Palestine; Department of Chemistry, Al-Azhar University of Gaza, P.O. Box 1277, Palestine; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar University of Gaza, P.O. Box 1277, Palestine; Medical Laboratory Sciences Department, Faculty of Health Sciences, Islamic University of Gaza, P.O. Box108, Palestine; Medical Laboratory Sciences Department, Faculty of Health Sciences, Israa University of Gaza, Gaza Strip, Palestine; School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames, London, United Kingdom; Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, United Kingdom
Morjan R.Y., Department of Chemistry, Islamic University of Gaza, P.O. Box108, Palestine; El-Hallaq A.F., Department of Chemistry, Al-Azhar University of Gaza, P.O. Box 1277, Palestine; Azarah J.N., Department of Chemistry, Islamic University of Gaza, P.O. Box108, Palestine; Almasri I.M., Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar University of Gaza, P.O. Box 1277, Palestine; Alzaharna M.M., Medical Laboratory Sciences Department, Faculty of Health Sciences, Islamic University of Gaza, P.O. Box108, Palestine; Al-Reefi M.R., Medical Laboratory Sciences Department, Faculty of Health Sciences, Israa University of Gaza, Gaza Strip, Palestine; Beadham I., School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames, London, United Kingdom; Abu-Teim O.S., Department of Chemistry, Al-Azhar University of Gaza, P.O. Box 1277, Palestine; Elmanama A.A., Medical Laboratory Sciences Department, Faculty of Health Sciences, Islamic University of Gaza, P.O. Box108, Palestine; Awadallah A.M., Department of Chemistry, Islamic University of Gaza, P.O. Box108, Palestine; Raftery J., Medical Laboratory Sciences Department, Faculty of Health Sciences, Israa University of Gaza, Gaza Strip, Palestine; Gardiner J.M., Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, United Kingdom
J.M. Gardiner; Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, United Kingdom; email: gardiner@manchester.ac.uk
6
10.1016/j.molstruc.2023.135754
Aromatic compounds; Cell culture; Chlorine compounds; Enzymes; Escherichia coli; Lanthanum compounds; Lead compounds; Aminopyrimidines; Anti-bacterial activity; Anticancer activities; Antitumour activity; E. coli; Fused pyrimidine; Hydrazonoyl chlorides; P.aeruginosa; Pyrimidine derivatives; S. aureus; Amino acids