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Israa University
2012
Archives of Pharmacal Research
Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents
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Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt; Department of Applied Pharmaceutical Sciences, Faculty of Pharmacy, Al-Israa University, Amman, Jordan
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10.1007/s12272-012-0805-4
Aminophylline; Ampicillin; Anilides; Animals; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Bronchodilator Agents; Disease Models, Animal; Gram-Negative Bacteria; Gram-Positive Bacteria; Guinea Pigs; Male; Mice; Structure-Activity Relationship; Theophylline; 2 (1,3 dimethyl 2,6 dioxo 2,3,6,7 tetrahydro 1h purin 8 ylsulfanyl) n m tolyl propionamide; aminophylline; anilide; antiinfective agent; bronchodilating agent; n (2 chlorophenyl) 2 (1,3 dimethyl 2,6 dioxo 2,3,6,7 6,7 tetrahydro 1h purin 8 ylsulfanyl)propionamide; n (4 acetylphenyl) 2 (1,3 dimethyl 2,6 dioxo 2,3,6,7 tetrahydro 1h purin 8 ylsulfanyl)propionamide; n (4 bromophenyl) 2 (1,3 dimethyl-2,6-dioxo-2,3 6,7-tetrahydro-1H-purin-8-ylsulfanyl)propionamide; n benzyl 2 (1,3 dimethyl 2,6 dioxo 2,3,6,7-tetrahydro 1h purin 8 ylsulfanyl) propionamide; n cyclohexyl 2 (1,3 dimethyl 2,6 dioxo 2,3,6,7 tetrahydro 1h purin 8 yl sulfanyl); nalidixic acid; theophylline derivative; unclassified drug; article; bronchospasm; chemical structure; clinical evaluation; controlled study; drug design; drug synthesis; Gram negative bacterium; Gram positive bacterium; in vitro study; infrared radiation; male; mass spectrometry; minimum inhibitory concentration; mouse; nonhuman; pharmacophore; proton nuclear magnetic resonance; structure activity relation