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Astaxanthin ameliorates necroptosis through bisphenol-A exposure by regulating brain RIPK1/FADD/RIPK3/MLKL pathway in adult male rats

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Al-Azhar University – Gaza
Eleyan M.; Ibrahim K.A.; Hussien M.; Zughbur M.R.; Ayesh B.M.; Abdelgaid H.A.
Eleyan, Mohammed (56491150800); Ibrahim, Khairy A. (57191636445); Hussien, Mohamed (57221935202); Zughbur, Mohammed R. (57201269785); Ayesh, Basim M. (6507464665); Abdelgaid, Hala A. (57204044363)
56491150800; 57191636445; 57221935202; 57201269785; 6507464665; 57204044363
2025
Environmental Analysis Health and Toxicology
Astaxanthin ameliorates necroptosis through bisphenol-A exposure by regulating brain RIPK1/FADD/RIPK3/MLKL pathway in adult male rats
40
3
Korean Society of Environmental Health and Toxicology
e2025024
Department of Laboratory Medical Sciences, Al-Aqsa University, Mustafa Hafez St, Gaza, Palestine; Faculty of Medicine, Al Azhar University, Jamal Abdl Naser St, Gaza, Palestine; Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Dokki, Giza, Egypt; Department of Chemistry, College of Science, King Khalid University, Abha, 61413, Saudi Arabia; Pesticide Formulation Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Dokki, Giza, Egypt; Egyptian Center for Disease Control (CDC), National Hepatology and Tropical Medicine Research Institute (NHTMRI), Corniche El Nil-Imbaba, Giza, Egypt
Eleyan M., Department of Laboratory Medical Sciences, Al-Aqsa University, Mustafa Hafez St, Gaza, Palestine, Faculty of Medicine, Al Azhar University, Jamal Abdl Naser St, Gaza, Palestine; Ibrahim K.A., Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Dokki, Giza, Egypt; Hussien M., Department of Chemistry, College of Science, King Khalid University, Abha, 61413, Saudi Arabia, Pesticide Formulation Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Dokki, Giza, Egypt; Zughbur M.R., Faculty of Medicine, Al Azhar University, Jamal Abdl Naser St, Gaza, Palestine; Ayesh B.M., Department of Laboratory Medical Sciences, Al-Aqsa University, Mustafa Hafez St, Gaza, Palestine; Abdelgaid H.A., Egyptian Center for Disease Control (CDC), National Hepatology and Tropical Medicine Research Institute (NHTMRI), Corniche El Nil-Imbaba, Giza, Egypt
K.A. Ibrahim; Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza, Dokki, Egypt; email: Khairy_moneim@yahoo.com
1
10.5620/eaht.2025024
Apoptosis; Astaxanthin; Bisphenol A; FADD/RIPKl/3/MLKL pathway; Necroptosis
acetylcholinesterase; astaxanthin; bisphenol A; caspase 3; caspase 9; dopamine; Fas associated death domain protein; glutathione peroxidase; glutathione transferase; mixed lineage kinase; mixed lineage kinase domain like pseudokinase; neurotransmitter; protein bcl 2; protein kinase; protein p53; receptor interacting protein kinase 1; receptor interacting protein kinase 3; serotonin; superoxide dismutase; unclassified drug; adult; animal experiment; animal model; animal tissue; apoptosis; Article; controlled study; drug exposure; enzyme linked immunosorbent assay; gene expression; hippocampus; lipid peroxidation; male; necroptosis; nonhuman; oxidative stress; protein expression; rat; real time polymerase chain reaction; signal transduction