Tumor-Intrinsic PD-1 Regulatory Network Drives Lapatinib Resistance in HER2⁺ Breast Cancer: An Integrative Bioinformatics Analysis

field_of_study

Blank

university

Al-Azhar University – Gaza

authors

Alhallaq A.S.; Sultan N.S.

authors_full_names

Alhallaq, Ahmed S. (60032441100); Sultan, Nadeen S. (60032156100)

authors_id

60032441100; 60032156100

year

2026

source_title

Asian Pacific journal of cancer prevention : APJCP

article_title

Tumor-Intrinsic PD-1 Regulatory Network Drives Lapatinib Resistance in HER2⁺ Breast Cancer: An Integrative Bioinformatics Analysis

volume

27

issue

2

page_start

613

page_end

627

affiliations

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Azhar University-Gaza, Gaza Strip, Palestine

authors_with_affiliations

Alhallaq A.S., Laboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Azhar University-Gaza, Gaza Strip, Palestine; Sultan N.S., Laboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Azhar University-Gaza, Gaza Strip, Palestine

cited_by

0

doi

10.31557/APJCP.2026.27.2.613

author_keywords

HER2+ breast cancer; lapatinib resistance; Tumor Microenvironment; Tumor-intrinsic PD-1, cancer cell-intrinsic PD-1

index_keywords

Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Computational Biology; Drug Resistance, Neoplasm; Erb-b2 Receptor Tyrosine Kinases; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lapatinib; Prognosis; Programmed Cell Death 1 Receptor; Protein Interaction Maps; Tumor Microenvironment; antineoplastic agent; epidermal growth factor receptor 2; ERBB2 protein, human; lapatinib; PDCD1 protein, human; programmed death 1 receptor; tumor marker; bioinformatics; breast tumor; drug resistance; drug therapy; female; gene expression regulation; gene regulatory network; genetics; human; metabolism; pathology; procedures; prognosis; protein analysis; tumor microenvironment