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Carvacrol modulates antioxidant enzymes, DNA integrity, and apoptotic markers in zearalenone-exposed fetal rat liver

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Al-Azhar University – Gaza
Eleyan M.; Zughbur M.R.; Hussien M.; Ayesh B.M.; Ibrahim K.A.
Eleyan, Mohammed (56491150800); Zughbur, Mohammed R. (57201269785); Hussien, Mohamed (57221935202); Ayesh, Basim M. (6507464665); Ibrahim, Khairy A. (57191636445)
56491150800; 57201269785; 57221935202; 6507464665; 57191636445
2025
Drug and Chemical Toxicology
Carvacrol modulates antioxidant enzymes, DNA integrity, and apoptotic markers in zearalenone-exposed fetal rat liver
48
3
547
556
Taylor and Francis Ltd.
Department of Laboratory Medical Sciences, Al-Aqsa University, Gaza, Palestine; Faculty of Medicine, Al Azhar University Gaza, Gaza, Palestine; Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia; Pesticide Formulation Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Giza, Egypt; Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza, Egypt
Eleyan M., Department of Laboratory Medical Sciences, Al-Aqsa University, Gaza, Palestine, Faculty of Medicine, Al Azhar University Gaza, Gaza, Palestine; Zughbur M.R., Faculty of Medicine, Al Azhar University Gaza, Gaza, Palestine; Hussien M., Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia, Pesticide Formulation Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Giza, Egypt; Ayesh B.M., Department of Laboratory Medical Sciences, Al-Aqsa University, Gaza, Palestine; Ibrahim K.A., Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza, Egypt
K.A. Ibrahim; Mammalian Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza, Dokki, 12618, Egypt; email: Khairy_moneim@yahoo.com
3
10.1080/01480545.2024.2425984
apoptosis; carvacrol; DNA damage; fetal liver; oxidative stress; Zearalenone
Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cymenes; DNA Damage; Female; Liver; Maternal Exposure; Monoterpenes; Oxidative Stress; Pregnancy; Rats; Rats, Wistar; Zearalenone; antioxidant; carvacrol; caspase 3; caspase 9; catalase; DNA; glutathione; glutathione transferase; malonaldehyde; protein Bax; protein bcl 2; protein p53; superoxide dismutase; SYBR green; zearalenone; antioxidant; carvacrol; cymene; monoterpene; zearalenone; animal experiment; animal model; animal tissue; apoptosis; Article; comet assay; controlled study; DNA content; DNA damage; enzyme activity; female; fetus; fetus liver; gene expression; gestation period; histopathology; immunohistochemistry; immunoreactivity; lipid liver level; lipid peroxidation; liver congestion; liver fatty degeneration; liver injury; liver necrosis; liver protection; male; maternal exposure; microphotography; nonhuman; oxidative stress; prenatal exposure; protein expression; rat; real time polymerase chain reaction; tail moment; adverse event; animal; chemical and drug induced liver injury; drug effect; embryology; enzymology; liver; metabolism; pathology; pregnancy; prevention and control; Wistar rat