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Famotidine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation

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Al-Azhar University – Gaza
Mohammad M.; Al-Masri I.M.; Issa A.; Al-Ghussein M.A.S.; Fararjeh M.; Alkhatib H.; Taha M.O.; Bustanji Y.
Mohammad, Mohammad (57202380878); Al-Masri, Ihab M. (36573119700); Issa, Ala (49061144700); Al-Ghussein, Mohamed A.S. (23567442300); Fararjeh, Mohammad (23100106000); Alkhatib, Hatim (57218854221); Taha, Mutasem O. (7102056385); Bustanji, Yasser (8847282600)
57202380878; 36573119700; 49061144700; 23567442300; 23100106000; 57218854221; 7102056385; 8847282600
2013
Journal of Enzyme Inhibition and Medicinal Chemistry
Famotidine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation
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4
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694
Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine; Faculty of Allied Health Sciences, Hashemite University, Zarqa, Jordan
Mohammad M., Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; Al-Masri I.M., Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine; Issa A., Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; Al-Ghussein M.A.S., Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine; Fararjeh M., Faculty of Allied Health Sciences, Hashemite University, Zarqa, Jordan; Alkhatib H., Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; Taha M.O., Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; Bustanji Y., Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan
M. Mohammad; Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; email: mkmohammad@ju.edu.jo
6
10.3109/14756366.2012.672413
Docking simulation; Famotidine; Glycogen synthase kinase; H2-receptor antagonist
Administration, Oral; Animals; Dose-Response Relationship, Drug; Famotidine; Glucose Tolerance Test; Glycogen; Glycogen Synthase Kinase 3; Liver; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Recombinant Proteins; Structure-Activity Relationship; Time Factors; amino acid; famotidine; glycogen; glycogen synthase kinase 3beta; animal experiment; article; controlled study; drug binding site; drug dose escalation; enzyme active site; enzyme inhibition; glycogen liver level; IC 50; in vitro study; male; molecular docking; mouse; nonhuman; oral glucose tolerance test; priority journal; simulation; single drug dose