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Synthesis, antibacterial and QSAR evaluation of 5-oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles

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Al-Azhar University – Gaza
Morjan R.Y.; Al-Attar N.H.; Abu-Teim O.S.; Ulrich M.; Awadallah A.M.; Mkadmh A.M.; Elmanama A.A.; Raftery J.; Abu-Awwad F.M.; Yaseen Z.J.; Elqidrea A.F.; Gardiner J.M.
Morjan, Rami Y. (55547465500); Al-Attar, Nisreen H. (56743011100); Abu-Teim, Omar S. (15844819400); Ulrich, Maschke (56742857600); Awadallah, Adel M. (6701728900); Mkadmh, Ahmed M. (8352161200); Elmanama, Abdelrauof A. (8717617200); Raftery, James (7004558116); Abu-Awwad, Fakhr M. (8280513700); Yaseen, Zyad J. (56743040800); Elqidrea, Ammar F. (42461227800); Gardiner, John M. (35310215400)
55547465500; 56743011100; 15844819400; 56742857600; 6701728900; 8352161200; 8717617200; 7004558116; 8280513700; 56743040800; 42461227800; 35310215400
2015
Bioorganic and Medicinal Chemistry Letters
Synthesis, antibacterial and QSAR evaluation of 5-oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles
25
18
4024
4028
Elsevier Ltd
22653
Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Chemistry Department, Faculty of Science, Al-Azhar University, PO Box 1277, Gaza, Palestine; UMET, UMR CNRS No8207, Université Lille 1 - Sciences et Technologies, Villeneuve d'Ascq Cedex, 59655, France; Chemistry Department, Faculty of Applied Science, Alaqsa University, PO Box 4051, Gaza, Palestine; Medical Laboratory Sciences Department, Faculty of Health Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; School of Chemistry, University of Manchester, Brunswick Street, Manchester, M13 9PL, United Kingdom; Manchester Institute of Biotechnology, School of Chemistry and EPS, University of Manchester, Manchester, M1 7DN, United Kingdom
Morjan R.Y., Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Al-Attar N.H., Chemistry Department, Faculty of Science, Al-Azhar University, PO Box 1277, Gaza, Palestine; Abu-Teim O.S., Chemistry Department, Faculty of Science, Al-Azhar University, PO Box 1277, Gaza, Palestine; Ulrich M., UMET, UMR CNRS No8207, Université Lille 1 - Sciences et Technologies, Villeneuve d'Ascq Cedex, 59655, France; Awadallah A.M., Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Mkadmh A.M., Chemistry Department, Faculty of Applied Science, Alaqsa University, PO Box 4051, Gaza, Palestine; Elmanama A.A., Medical Laboratory Sciences Department, Faculty of Health Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Raftery J., School of Chemistry, University of Manchester, Brunswick Street, Manchester, M13 9PL, United Kingdom; Abu-Awwad F.M., Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Yaseen Z.J., Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine; Elqidrea A.F., UMET, UMR CNRS No8207, Université Lille 1 - Sciences et Technologies, Villeneuve d'Ascq Cedex, 59655, France; Gardiner J.M., Manchester Institute of Biotechnology, School of Chemistry and EPS, University of Manchester, Manchester, M1 7DN, United Kingdom
J.M. Gardiner; Manchester Institute of Biotechnology, School of Chemistry and EPS, University of Manchester, Manchester, M1 7DN, United Kingdom; email: gardiner@manchester.ac.uk
26
10.1016/j.bmcl.2015.04.070
Antibacterial; QSAR; Tetrazole; Tetrazolethiones; Tetrazolones
Anti-Bacterial Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Tetrazoles; Bacillus subtilis; Bacteria (microorganisms); Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; Negibacteria; Posibacteria; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus; acetic anhydride; antiinfective agent; benzyl bromide; chloroacetic acid; succinic anhydride; tetrazole derivative; antiinfective agent; tetrazole derivative; alkylation; antibacterial activity; Article; Bacillus subtilis; bacterial strain; broth dilution; carbon nuclear magnetic resonance; controlled study; crystal structure; drug synthesis; Enterococcus faecalis; Escherichia coli; in vitro study; infrared spectroscopy; inhibition zone; Klebsiella pneumoniae; mass spectrometry; minimum inhibitory concentration; nonhuman; Proteus mirabilis; proton nuclear magnetic resonance; Pseudomonas aeruginosa; quantitative structure activity relation; Staphylococcus aureus; Streptococcus; chemical structure; chemistry; dose response; drug effects; Gram negative bacterium; Gram positive bacterium; microbial sensitivity test; synthesis; X ray crystallography