New leads for DPP IV inhibition: Structure-based pharmacophore mapping and virtual screening study

field_of_study

Blank

university

Al-Azhar University – Gaza

authors

Almasri I.M.; Taha M.O.; Mohammad M.K.

authors_full_names

Almasri, Ihab M. (36573119700); Taha, Mutasem O. (7102056385); Mohammad, Mohammad K. (57202380878)

authors_id

36573119700; 7102056385; 57202380878

year

2013

source_title

Archives of Pharmacal Research

article_title

New leads for DPP IV inhibition: Structure-based pharmacophore mapping and virtual screening study

volume

36

issue

11

page_start

1326

page_end

1337

affiliations

Department of Chemistry and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Gaza, Gaza Strip, Palestine; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan

authors_with_affiliations

Almasri I.M., Department of Chemistry and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Gaza, Gaza Strip, Palestine; Taha M.O., Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan; Mohammad M.K., Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan

corresponding_author

I.M. Almasri; Department of Chemistry and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Gaza, Gaza Strip, Palestine; email: i.masri@alazhar-gaza.edu

cited_by

14

doi

10.1007/s12272-013-0224-1

author_keywords

DPP IV; High-throughput docking; Lead inhibitors; Structure-based pharmacophore; Virtual screening

index_keywords

Databases, Pharmaceutical; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Hypoglycemic Agents; Models, Molecular; Molecular Structure; Structure-Activity Relationship; dipeptidyl peptidase IV inhibitor; gemifloxacin; glucose; nci 0047527; nci 0067053; nci 0134131; nci 0163391; nci 0211295; nci 0211844; paroxetine; unclassified drug; article; computer program; drug binding site; drug screening; enzyme inhibition; glucose blood level; high throughput screening; hydrogen bond; molecular docking; molecular weight; nonhuman; pharmacophore; X ray crystallography