Blank
Al-Azhar University – Gaza
2019
PLoS ONE
Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations
13
8
Public Library of Science
e0202572
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Department of Pharmacology and Toxicology, Dubai Pharmacy College, Dubai, United Arab Emirates; Department of Pharmaceutical Chemistry and Natural Products, Dubai Pharmacy College, Dubai, United Arab Emirates; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al Azhar University, Gaza, Palestine; Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan; Hamdi Mango Center for Scientific Research, University of Jordan, Amman, Jordan
48
10.1371/journal.pone.0202572
Animals; Anti-Infective Agents; Disease Models, Animal; Gout; Humans; Hyperuricemia; Mice; Molecular Docking Simulation; Plant Extracts; Tribulus; Triterpenes; Xanthine Oxidase; oteracil potassium; plant extract; Tribulus arabicus extract; unclassified drug; ursolic acid; xanthine oxidase; xanthine oxidase inhibitor; antiinfective agent; plant extract; triterpene; ursolic acid; xanthine oxidase; analysis of variance; animal experiment; animal model; antihyperuricemic activity; Article; binding site; controlled study; drug activity; drug potency; drug protein binding; enzyme inhibition; hyperuricemia; IC50; in vitro study; in vivo study; liquid chromatography; male; molecular docking; mouse; nonhuman; simulation; structure activity relation; Tribulus; Tribulus arabicus; X ray crystallography; animal; antagonists and inhibitors; chemistry; disease model; genetics; gout; human; hyperuricemia; molecular docking; pathology