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Capillary electrophoresis to investigate biopharmaceuticals and pharmaceutically-relevant binding properties

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Al-Azhar University – Gaza
Deeb S.E.; Wätzig H.; El-Hady D.A.
Deeb, Sami El (14059838300); Wätzig, Hermann (55963552800); El-Hady, Deia Abd (6506274654)
14059838300; 55963552800; 6506274654
2013
TrAC - Trends in Analytical Chemistry
Capillary electrophoresis to investigate biopharmaceuticals and pharmaceutically-relevant binding properties
48
112
131
Elsevier B.V.
Department of Pharmaceutical Chemistry, Al-Azhar University-Gaza, Gaza, Palestine; Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, D-38106 Braunschweig, Germany; Chemistry Department, Faculty of Science-North Jeddah, King Abdulaziz University, Jeddah, Saudi Arabia; Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt
Deeb S.E., Department of Pharmaceutical Chemistry, Al-Azhar University-Gaza, Gaza, Palestine; Wätzig H., Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, D-38106 Braunschweig, Germany; El-Hady D.A., Chemistry Department, Faculty of Science-North Jeddah, King Abdulaziz University, Jeddah, Saudi Arabia, Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt
H. Wätzig; Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, D-38106 Braunschweig, Germany; email: H.Waetzig@tu-bs.de
54
10.1016/j.trac.2013.04.005
Affinity capillary electrophoresis (ACE); Binding constant; Biopharmaceuticals; Capillary electrophoresis (CE); Drug target; Early screening; Impurity assessment; Method validation; Pharmacokinetics; Precision
Binding energy; Pharmacokinetics; acetic acid; acetylsalicylic acid; biological product; biopharmaceutical product; calcium; copper; dodecyl sulfate sodium; drug; ephedrine; ethambutol; glutamic acid; ibuprofen; iodide; leuprorelin; magnesium; manganese; monoclonal antibody; nickel; nitrate; ovalbumin; phosphate; pilocarpine; pirenzepine; recombinant granulocyte macrophage colony stimulating factor; salicylic acid; sodium hydroxide; succinic acid; thiocyanate; tryptophan; unclassified drug; unindexed drug; Affinity capillary electrophoresis; Binding constant; Biopharmaceuticals; Drug targets; Method validations; Precision; analytical parameters; binding affinity; body fluid; capillary electrophoresis; drug binding; drug identification; drug purity; drug stability; human; intermethod comparison; performance; priority journal; proteomics; quality control; reliability; review; validation study; Capillary electrophoresis