Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells

field_of_study

Blank

university

Al-Azhar University – Gaza

authors

Al-Qatati A.; Aliwaini S.

authors_full_names

Al-Qatati, Abeer (54400011100); Aliwaini, Saeb (55910683600)

authors_id

54400011100; 55910683600

year

2017

source_title

Oncology Letters

article_title

Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells

volume

14

issue

6

page_start

7993

page_end

7999

publisher

Spandidos Publications

affiliations

Faculty of Applied Medical Sciences, Al-Azhar University, Gaza, 1277, Palestine; Department of Biological Sciences and Biotechnology, Faculty of Sciences, Islamic University of Gaza, Gaza, 108, Palestine

authors_with_affiliations

Al-Qatati A., Faculty of Applied Medical Sciences, Al-Azhar University, Gaza, 1277, Palestine; Aliwaini S., Department of Biological Sciences and Biotechnology, Faculty of Sciences, Islamic University of Gaza, Gaza, 108, Palestine

corresponding_author

S. Aliwaini; Department of Biological Sciences and Biotechnology, Faculty of Sciences, Islamic University of Gaza, Gaza, Rimal Street, 108, Palestine; email: saib.iwini@gmail.com

cited_by

44

doi

10.3892/ol.2017.7189

author_keywords

Apoptosis; Autophagy; Dacarbazine; Melanoma; Pitavastatin

index_keywords

caspase 3; cytochrome c; dacarbazine; fluorescein isothiocyanate; lipocortin 5; pitavastatin; antineoplastic activity; apoptosis; Article; autophagy; cell death; cell survival; controlled study; cytotoxicity; drug efficacy; drug potentiation; flow cytometry; G1 phase cell cycle checkpoint; human; human cell; melanoma; metastatic melanoma; MTT assay; Western blotting