Computational approaches for the discovery of natural pancreatic lipase inhibitors as antiobesity agents

Anti-Obesity Agents; Biological Products; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Lipase; Models, Molecular; Obesity; Pancreas; 1,4 naphthoquinone derivative; 2 hexadecenoic acid; alkaloid; antiobesity agent; aurantiamide; berberine; bisindole alkaloid derivative; cnidiadin; dihydroberberine; diterpenoid; esterase inhibitor; ginkgolide A; glycoside; indole derivative; kushenol K; leachianone G; munjistin; natural product; pancreatic lipase inhibitor; papaverine; plant extract; polyphenol derivative; polysaccharide; reserpic acid; rosmarinic acid; saponin; tetrahydrolipstatin; triacylglycerol lipase; triterpene; unclassified drug; unindexed drug; antiobesity agent; biological product; enzyme inhibitor; triacylglycerol lipase; amino acid sequence; computer aided design; computer analysis; crystal structure; drug activity; drug design; drug potency; drug screening; drug structure; enzyme inhibition; human; molecular docking; molecular dynamics; molecular model; nonhuman; obesity; pharmacophore modeling; prediction; priority journal; Review; structure activity relation; chemistry; drug development; enzymology; metabolism; obesity; pancreas; synthesis