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Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety

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Al-Azhar University – Gaza
Kaplancikli Z.A.; Yurttaş L.; Özdemir A.; Turan-Zitouni G.; Çiftçi G.A.; Yildirim S.U.; Mohsen U.A.
Kaplancikli, Zafer Asim (6602311259); Yurttaş, Leyla (35811419600); Özdemir, Ahmet (7006505091); Turan-Zitouni, Gülhan (7003906101); Çiftçi, Gülşen Akalin (55097531300); Yildirim, Şafak Ulusoylar (54391915700); Mohsen, Usama Abu (6505829502)
6602311259; 35811419600; 7006505091; 7003906101; 55097531300; 54391915700; 6505829502
2014
Medicinal Chemistry Research
Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety
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2
1067
1075
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine
Kaplancikli Z.A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Yurttaş L., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Özdemir A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Turan-Zitouni G., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Çiftçi G.A., Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Yildirim S.U., Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; Mohsen U.A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine
Z.A. Kaplancikli; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey; email: zakaplan@anadolu.edu.tr
24
10.1007/s00044-013-0717-y
Antiproliferative activity; Caspase-3; Hydrazone; MTT assay; Tetrazole
antineoplastic agent; caspase 3; hydrazone derivative; mitoxantrone; n' (2 chlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (2 hydroxy 3,5 dichlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (2,3 dichlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (3 chloro 4 methylamionobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (3 chlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (3,4 dichlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (3,5 dichlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; n' (4 chlorobenzylidene) 4 [(1 phenyl 1h tetrazole 5 yl)thio]butanohydrazide; tetrazole derivative; unclassified drug; antineoplastic activity; antiproliferative activity; article; carbon nuclear magnetic resonance; cell cycle M phase; cell viability; controlled study; DNA synthesis; DNA synthesis inhibition; drug cytotoxicity; drug potency; drug screening; drug synthesis; enzyme activation; G1 phase cell cycle checkpoint; human; human cell; IC 50; mass spectrometry; MTT assay; proton nuclear magnetic resonance