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Strategies in method development to quantify enantiometric impurities using CE

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Al-Azhar University – Gaza
El Deeb S.; Hasemann P.; Wätzig H.
El Deeb, Sami (14059838300); Hasemann, Phillip (16506588400); Wätzig, Hermann (55963552800)
14059838300; 16506588400; 55963552800
2008
Electrophoresis
Strategies in method development to quantify enantiometric impurities using CE
29
17
3552
3562
Wiley-VCH Verlag
Department of Pharmaceutical Chemistry, Al-Azhar University-Gaza, Gaza, Palestine; Institute of Pharmaceutical Chemistry, Technical University Braunschweig, D-38106 Braunschweig, Beethovenstrasse 55, Germany
El Deeb S., Department of Pharmaceutical Chemistry, Al-Azhar University-Gaza, Gaza, Palestine; Hasemann P., Institute of Pharmaceutical Chemistry, Technical University Braunschweig, D-38106 Braunschweig, Beethovenstrasse 55, Germany; Wätzig H., Institute of Pharmaceutical Chemistry, Technical University Braunschweig, D-38106 Braunschweig, Beethovenstrasse 55, Germany
H. Wätzig; Institute of Pharmaceutical Chemistry, Technical University Braunschweig, D-38106 Braunschweig, Beethovenstrasse 55, Germany; email: H.Waetzig@tu-bs.de
43
10.1002/elps.200800081
Chiral drugs; Chiral selectors; Enantiomeric impurities determination; Enantiomeric separation
Enantiomers; Impurities; Signal to noise ratio; alprenolol; atenolol; buffer; cyclodextrin; ephedrine; ibuprofen; isoprenaline; ketoprofen; mandelic acid; methadone; naproxen; phosphate; pindolol; promethazine; propranolol; tryptophan; verapamil; Chiral drugs; Chiral selector; Common strategy; Drug substances; Enantiomeric impurity determination; Enantiomeric separation; Enantiomerics; Enantioselective; Impurity determination; Method development; article; capillary electrophoresis; chirality; controlled study; drug determination; drug impurity; enantioselectivity; process optimization; quantitative analysis; racemic mixture; separation technique; signal noise ratio; Capillary electrophoresis