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Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative

Biochemistry
Al-Aqsa
Abu Ajaj, K.; El-Abadla, N.; Welker, P.; Azab, S.; Zeisig, R.; Fichtner, I.; Kratz, F.
Abu Ajaj, Khalid (13609255600); El-Abadla, Naser Said (13408232100); Welker, Pia (7004171533); Azab, Samar Saad Eldeen (8679174000); Zeisig, Reiner (56360443700); Fichtner, Iduna (7006406686); Kratz, Felix (7006199795)
13609255600; 13408232100; 7004171533; 8679174000; 56360443700; 7006406686; 7006199795
2012
European Journal of Cancer
Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative
48
13
2054
2065
Klinik für Tumorbiologie, Freiberg am Neckar, Baden-Wurttemberg, Germany; Department of Chemistry, Al-Aqsa University, Gaza Strip, Palestine; Drug Discovery, Mivenion GmbH, Berlin, Germany; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Cairo, Egypt; Max Delbruck Center for Molecular Medicine, Berlin, Germany
Abu Ajaj, Khalid, Klinik für Tumorbiologie, Freiberg am Neckar, Baden-Wurttemberg, Germany; El-Abadla, Naser Said, Department of Chemistry, Al-Aqsa University, Gaza Strip, Palestine; Welker, Pia, Drug Discovery, Mivenion GmbH, Berlin, Germany; Azab, Samar Saad Eldeen, Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Cairo, Egypt; Zeisig, Reiner, Max Delbruck Center for Molecular Medicine, Berlin, Germany; Fichtner, Iduna, Max Delbruck Center for Molecular Medicine, Berlin, Germany; Kratz, Felix, Klinik für Tumorbiologie, Freiberg am Neckar, Baden-Wurttemberg, Germany
F. Kratz; Tumor Biology Center, 79106 Freiburg, Breisacher Strasse 117, Germany; email: kratz@tumorbio.uni-freiburg.de
12
10.1016/j.ejca.2011.08.003