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Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study

Medicine
Islamic University of Gaza
Lane, J.C.E.; Weaver, J.; Kostka, K.; Duarte-Salles, T.; Abrahao, M.T.F.; Alghoul, H.; Alser, O.; Alshammari, T.M.; Biedermann, P.; Banda, J.M.; Burn, E.; Casajust, P.; Conover, M.M.; Culhane, A.C.; Davydov, A.; DuVall, S.; Dymshyts, D.; Fernández-Bertolín, S.; Fišter, K.; Hardin, J.; Hester, L.; Hripcsak, G.; Kaas-Hansen, B.S.; Kent, S.; Khosla, S.; Kolovos, S.; Lambert, C.G.; van der Lei, J.; Lynch, K.; Makadia, R.; Margulis, A.V.; Matheny, M.; Mehta, P.P.; Morales, D.; Morgan-Stewart, H.; Mosseveld, M.; Newby, D.; Nyberg, F.; Ostropolets, A.; Park, R.W.; Prats-Uribe, A.; Rao, G.A.; Reich, C.; Reps, J.; Rijnbeek, P.; Sathappan, S.M.K.; Schuemie, M.J.; Seager, S.; Sena, A.; Shoaibi, A.; Spotnitz, M.; Suchard, M.; Torre, C.O.; Vizcaya, D.; Wen, H.; de Wilde, M.; Xie, J.; You, S.; Zhang, L.; Zhuk, O.; Ryan, P.; Prieto-Alhambra, D.
Lane, Jennifer C.E. (57203722963); Weaver, James (55708048600); Kostka, Kristin Feeney (57213197465); Duarte-Salles, Talita (36767041500); Abrahao, Maria Tereza F. (57193842743); Alghoul, Heba (57218772407); Alser, Osaid H. (57201662092); Alshammari, Thamir M. (57192974444); Biedermann, Patricia (56401939100); Banda, Juan M. (35197796500); Burn, Edward A.O. (57189518535); Casajust, Paula (57218767493); Conover, Mitchell M. (56144544600); Culhane, Aedín C. (6601969704); Davydov, Alexander V. (57197786144); DuVall, Scott L. (22034265800); Dymshyts, Dmitry (57209615073); Fernández-Bertolín, Sergio (57210897709); Fišter, Kristina (59881871900); Hardin, Jill H. (57207570236); Hester, Laura L. (55934779200); Hripcsak, George M. (7004471151); Kaas-Hansen, Benjamin Skov (57205673082); Kent, Seamus (57210744185); Khosla, Sajan (55582673800); Kolovos, Spyros (57189061884); Lambert, Christophe G. (59583243400); van der Lei, Johan L. (56592306600); Lynch, Kristine E. (57194852183); Makadia, Rupa (56705564300); Margulis, Andrea V. (35180184600); Matheny, Michael Edwin (57210774976); Mehta, Paras P. (57218760684); Morales, Daniel R. (36992175400); Morgan-Stewart, Henry (56328686900); Mosseveld, Mees (6508283247); Newby, Danielle (55341862800); Nyberg, Fredrik (7103022770); Ostropolets, Anna (57212550817); Park, Rae Woong (9249349100); Prats-Uribe, A. (57195108696); Rao, Gowtham Adamane (36848817900); Reich, Christian G. (37021769500); Reps, Jenna Marie (43061445600); Rijnbeek, Peter R. (6603033335); Sathappan, Selva Muthu Kumaran (57218770987); Schuemie, Martijn J. (35238890300); Seager, Sarah L. (59432633300); Sena, Anthony G. (57200965634); Shoaibi, Azza (36176248800); Spotnitz, Matthew Emerson (36144387500); Suchard, Marc A. (6603887291); Torre, Carmen Olga (57218763376); Vizcaya, David (57214700930); Wen, Haini (57211690653); de Wilde, Marcel (8421222600); Xie, Junqing (57201493745); You, Seng-chan (57200255244); Zhang, Lin (58039593800); Zhuk, Oleg (57218766194); Ryan, Patrick Barry (36469223700); Prieto-Alhambra, Daniel (35788288300)
57203722963; 55708048600; 57213197465; 36767041500; 57193842743; 57218772407; 57201662092; 57192974444; 56401939100; 35197796500; 57189518535; 57218767493; 56144544600; 6601969704; 57197786144; 22034265800; 57209615073; 57210897709; 59881871900; 57207570236; 55934779200; 7004471151; 57205673082; 57210744185; 55582673800; 57189061884; 59583243400; 56592306600; 57194852183; 56705564300; 35180184600; 57210774976; 57218760684; 36992175400; 56328686900; 6508283247; 55341862800; 7103022770; 57212550817; 9249349100; 57195108696; 36848817900; 37021769500; 43061445600; 6603033335; 57218770987; 35238890300; 59432633300; 57200965634; 36176248800; 36144387500; 6603887291; 57218763376; 57214700930; 57211690653; 8421222600; 57201493745; 57200255244; 58039593800; 57218766194; 36469223700; 35788288300
2020
The Lancet Rheumatology
Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study
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Lancet Publishing Group
University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Real World Solutions, IQVIA Inc., Durham, NC, United States; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Barcelona, Spain; Faculty of Medicine, Universidade de São Paulo, Sao Paulo, SP, Brazil; Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine; Harvard Medical School, Boston, MA, United States; Medication Safety Research Chair, King Saud University, Riyadh, Riyad, Saudi Arabia; Actelion Pharmaceuticals Ltd., Allschwil, Switzerland; Department of Computer Science, Georgia State University, Atlanta, GA, United States; Real-World Evidence, Barcelona, Spain; Department of Data Science, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Medical Ontology solutions, Odysseus Data Services, Cambridge, MA, United States; U.S. Department of Veterans Affairs, Washington, D.C., DC, United States; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States; University of Zagreb School of Medicine, Zagreb, Croatia; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, United States; New York Presbyterian Hospital, New York, NY, United States; Clinical Pharmacology Unit, Sjællands Universitetshospital, Roskilde, Sjaelland, Denmark; NNF Center for Protein Research, Københavns Universitet, Copenhagen, Hovedstaden, Denmark; National Institute for Health and Care Excellence (NICE), London, United Kingdom; AstraZeneca, Cambridge, Cambridgeshire, United Kingdom; Department of Internal Medicine, Center for Global Health and Division of Translational Informatics, Albuquerque, NM, United States; Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; RTI Health Solutions, Research Triangle Park, NC, United States; Geriatrics Research Education and Clinical Care Center, VA Tennessee Valley Healthcare, Nashville, TN, United States; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States; University of Arizona College of Medicine – Tucson, Tucson, AZ, United States; Division of Population Health and Genomics, University of Dundee, Dundee, Scotland, United Kingdom; University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; School of Public Health and Community Medicine, Sahlgrenska Akademin, Gothenburg, Vastra Gotaland, Sweden; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Gyeonggi-do, South Korea; Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore; David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Bayer Pharmaceuticals, Barcelona, Spain; Department of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Melbourne School of Population and Global Health, Melbourne, VIC, Australia
Lane, Jennifer C.E., University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; Weaver, James, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Kostka, Kristin Feeney, Real World Solutions, IQVIA Inc., Durham, NC, United States; Duarte-Salles, Talita, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Barcelona, Spain; Abrahao, Maria Tereza F., Faculty of Medicine, Universidade de São Paulo, Sao Paulo, SP, Brazil; Alghoul, Heba, Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine; Alser, Osaid H., Harvard Medical School, Boston, MA, United States; Alshammari, Thamir M., Medication Safety Research Chair, King Saud University, Riyadh, Riyad, Saudi Arabia; Biedermann, Patricia, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland; Banda, Juan M., Department of Computer Science, Georgia State University, Atlanta, GA, United States; Burn, Edward A.O., University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Barcelona, Spain; Casajust, Paula, Real-World Evidence, Barcelona, Spain; Conover, Mitchell M., Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Culhane, Aedín C., Department of Data Science, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Davydov, Alexander V., Medical Ontology solutions, Odysseus Data Services, Cambridge, MA, United States; DuVall, Scott L., U.S. Department of Veterans Affairs, Washington, D.C., DC, United States, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States; Dymshyts, Dmitry, Medical Ontology solutions, Odysseus Data Services, Cambridge, MA, United States; Fernández-Bertolín, Sergio, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Barcelona, Spain; Fišter, Kristina, University of Zagreb School of Medicine, Zagreb, Croatia; Hardin, Jill H., Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Hester, Laura L., Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Hripcsak, George M., Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, United States, New York Presbyterian Hospital, New York, NY, United States; Kaas-Hansen, Benjamin Skov, Clinical Pharmacology Unit, Sjællands Universitetshospital, Roskilde, Sjaelland, Denmark, NNF Center for Protein Research, Københavns Universitet, Copenhagen, Hovedstaden, Denmark; Kent, Seamus, National Institute for Health and Care Excellence (NICE), London, United Kingdom; Khosla, Sajan, AstraZeneca, Cambridge, Cambridgeshire, United Kingdom; Kolovos, Spyros, University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; Lambert, Christophe G., Department of Internal Medicine, Center for Global Health and Division of Translational Informatics, Albuquerque, NM, United States; van der Lei, Johan L., Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; Lynch, Kristine E., U.S. Department of Veterans Affairs, Washington, D.C., DC, United States, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States; Makadia, Rupa, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Margulis, Andrea V., RTI Health Solutions, Research Triangle Park, NC, United States; Matheny, Michael Edwin, Geriatrics Research Education and Clinical Care Center, VA Tennessee Valley Healthcare, Nashville, TN, United States, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States; Mehta, Paras P., University of Arizona College of Medicine – Tucson, Tucson, AZ, United States; Morales, Daniel R., Division of Population Health and Genomics, University of Dundee, Dundee, Scotland, United Kingdom; Morgan-Stewart, Henry, Real World Solutions, IQVIA Inc., Durham, NC, United States; Mosseveld, Mees, Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; Newby, Danielle, University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; Nyberg, Fredrik, School of Public Health and Community Medicine, Sahlgrenska Akademin, Gothenburg, Vastra Gotaland, Sweden; Ostropolets, Anna, Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, United States; Park, Rae Woong, Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Gyeonggi-do, South Korea; Prats-Uribe, A., University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; Rao, Gowtham Adamane, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Reich, Christian G., Real World Solutions, IQVIA Inc., Durham, NC, United States; Reps, Jenna Marie, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Rijnbeek, Peter R., Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; Sathappan, Selva Muthu Kumaran, Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore; Schuemie, Martijn J., Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Seager, Sarah L., Real World Solutions, IQVIA Inc., Durham, NC, United States; Sena, Anthony G., Janssen Pharmaceuticals, Inc., Titusville, NJ, United States, Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; Shoaibi, Azza, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States; Spotnitz, Matthew Emerson, Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, United States; Suchard, Marc A., David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Torre, Carmen Olga, Real World Solutions, IQVIA Inc., Durham, NC, United States; Vizcaya, David, Bayer Pharmaceuticals, Barcelona, Spain; Wen, Haini, Department of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; de Wilde, Marcel, Department of Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; Xie, Junqing, University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; You, Seng-chan, Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Gyeonggi-do, South Korea; Zhang, Lin, School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Melbourne School of Population and Global Health, Melbourne, VIC, Australia; Zhuk, Oleg, Medical Ontology solutions, Odysseus Data Services, Cambridge, MA, United States; Ryan, Patrick Barry, Janssen Pharmaceuticals, Inc., Titusville, NJ, United States, Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, United States; Prieto-Alhambra, Daniel, University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Barcelona, Spain
P. Ryan; Janssen Research and Development, Titusville, United States; email: ryan@ohdsi.org
120
10.1016/S2665-9913(20)30276-9