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Tri- and tetrasubstituted pyrazole derivates: Regioisomerism switches activity from p38MAP kinase to important cancer kinases

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Islamic University of Gaza
Thaher B.A.; Arnsmann M.; Totzke F.; Ehlert J.E.; Kubbutat M.H.G.; Schächtele C.; Zimmermann M.O.; Koch P.; Boeckler F.M.; Laufer S.A.
Thaher, Bassam Abu (6506019390); Arnsmann, Martina (54934564900); Totzke, Frank (8891236600); Ehlert, Jan E. (7004047594); Kubbutat, Michael H. G. (6603387922); Schächtele, Christoph (7005005278); Zimmermann, Markus O. (42862878100); Koch, Pierre (23477556700); Boeckler, Frank M. (6506347097); Laufer, Stefan A. (26643249000)
6506019390; 54934564900; 8891236600; 7004047594; 6603387922; 7005005278; 42862878100; 23477556700; 6506347097; 26643249000
2012
Journal of Medicinal Chemistry
Tri- and tetrasubstituted pyrazole derivates: Regioisomerism switches activity from p38MAP kinase to important cancer kinases
55
2
961
965
Faculty of Science, Chemistry Department, Islamic University of Gaza, Gaza Strip, Palestine; Department Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Auf der Morgenstelle 8, Germany; ProQinase GmbH, 79106 Freiburg, Breisacher Strasse 117, Germany; Laboratory for Molecular Design and Pharmaceutical Biophysics Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tübingen, Germany
Thaher B.A., Faculty of Science, Chemistry Department, Islamic University of Gaza, Gaza Strip, Palestine; Arnsmann M., Department Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Auf der Morgenstelle 8, Germany; Totzke F., ProQinase GmbH, 79106 Freiburg, Breisacher Strasse 117, Germany; Ehlert J.E., ProQinase GmbH, 79106 Freiburg, Breisacher Strasse 117, Germany; Kubbutat M.H.G., ProQinase GmbH, 79106 Freiburg, Breisacher Strasse 117, Germany; Schächtele C., ProQinase GmbH, 79106 Freiburg, Breisacher Strasse 117, Germany; Zimmermann M.O., Laboratory for Molecular Design and Pharmaceutical Biophysics Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tübingen, Germany; Koch P., Department Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Auf der Morgenstelle 8, Germany; Boeckler F.M., Laboratory for Molecular Design and Pharmaceutical Biophysics Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tübingen, Germany; Laufer S.A., Department Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Auf der Morgenstelle 8, Germany
S.A. Laufer; Department Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Auf der Morgenstelle 8, Germany; email: stefan.laufer@uni-tuebingen.de
76
10.1021/jm201391u